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Project

Combating antibiotic resistance in Philippine lakes: One Health upstream interventions to reduce the burden
 

Philippines
Project ID
109859
Total Funding
CAD 499,200.00
IDRC Officer
Armando Heriazon
Project Status
Active
Duration
36 months

Programs and partnerships

Lead institution(s)

Project leader:
Windell Rivera
Philippines

Summary

Lakes provide essential natural resources for populations in low- and middle-income countries (LMICs), but there is growing concern of contamination with antimicrobial resistant (AMR) determinants from animal and human sources, especially beta-lactams and carbapenems that are the cornerstone ofRead more

Lakes provide essential natural resources for populations in low- and middle-income countries (LMICs), but there is growing concern of contamination with antimicrobial resistant (AMR) determinants from animal and human sources, especially beta-lactams and carbapenems that are the cornerstone of human antimicrobial therapy. A growing body of literature supports that beta-lactam resistance in Asian lakes and rivers is increasing, but few interventions have been evaluated to determine whether it is possible to reduce environmental contamination from hospitals and agriculture. This project proposes to develop interventions and evaluate their impact on AMR from humans, animals and the environment. Interventions include antimicrobial stewardship programs in hospitals and backyard farms, campaigns to educate the public on AMR, improving management practices on farms and cleaning effluents that feed the lake. AMR in human and veterinary settings and lake water will be evaluated using conventional microbiology and molecular biology methods.

The conditions in and around Laguna Lake in the Philippines resemble those of many Asian, Latin American, and African countries, allowing project results to be applicable to other LMICs and promote the UN sustainable development goals worldwide. The One Health approach is essential to tackle AMR in the human-animal-environment interface: lower pollution loads will improve water quality and lake resources and reduce disease outbreaks, benefiting the Laguna lakeshore communities of over 16 million people.

This is one of three projects receiving funding support from IDRC through the Joint Programming Initiative on Antimicrobial Resistance (JPIAMR), an international collaborative platform that coordinates global funding to support collaborative research and action on AMR. Through the JPIAMR, IDRC has partnered with 30 other donor agencies to fund innovative research projects to understand the impact of interventions on the development and transmission of AMR and to design, implement, evaluate and compare interventions that will have a true impact on reducing the development and transmission of AMR in and between One Health settings.